IMAGE

Fig 2

ID

ZDB-IMAGE-260118-136

Genes

pomgnt2

Publication

Flannery et al., 2026 - Impact of maternal compensation on developmental phenotypes in a zebrafish model of severe congenital muscular dystrophy

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Figures for Flannery et al., 2026

Image

Figure Caption

Fig 2 Developmental phenotypes caused by elimination of maternal pomgnt2.

A: qPCR analysis showing high pomgnt2 mRNA expression in oocytes and increasing zygotic expression between 24 and 96 hpf. (***p < 0.001) B: Immunofluorescent staining of muscle showing that ZKOs have residual α-DG glycosylation due to maternally provided pomgnt2, but this is depleted in MZKOs without maternal pomgnt2 (10X magnification, scale bar: 100 µm). C: Survival analysis showing that MZKOs begin to deviate from the Mendelian 50/50 survival ratio between 10-14 dpf, with most MZKOs dead by 28 dpf. D: Body length measurements showing a trend toward reduction in MZKOs at 14 dpf and a significant reduction at 28 dpf (***p < 0.001).

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

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