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Figure Caption
Fig. 3 Colocalization of RRP12 and nucleolar markers. (A) Representative immunofluorescence of RRP12 (green) and nucleolin (red) in the control and affected samples. Nucleolar structures are less defined and morphologically disrupted in patients' fibroblasts (A.II.2, C.II.1, C.II.2) compared to the control. Scale bar: 50 and 25 μm. (B) Quantification of number of nucleoli per cell in proband A.II.2 compared to control (P = <0.0001). *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001.
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