ZFIN Image: Kröll-Hermi et al., 2025, Fig. 2

Image

Figure Caption

Fig. 2 Structural characterization of PRMT9, highlighting the identified missense sites (A) Crystal structure of the Apo-PRMT9 shown in cartoon representation and color coded according to its domain architecture as labeled. The unresolved linker joining the two modules is displayed as a black dashed line. (B) Electrostatic surface potential representation of the Apo-PRMT9 shown in the same orientation as in (A). Surface color indicates electrostatic potential ranging from −10 kT/e (red) to +10 kT/e (blue). Electrostatic surface potentials were calculated using APBS.36 (C) Overlay of the Apo-PRMT9 monomer, color coded the same as in (A), on MmPRMT7 (gray) (PDB: 4C4A). (D) Overview of all six missense variants, shown as sticks and colored magenta, distributed among Apo-PRMT9 monomer and color coded the same as in (A).

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Am. J. Hum. Genet.