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Publication: Kröll-Hermi et al., 2025 - Bi-allelic PRMT9 loss-of-function variants cause a syndromic form of intellectual disability
All Figures: Figures for Kröll-Hermi et al., 2025

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Fig. 2 Structural characterization of PRMT9, highlighting the identified missense sites (A) Crystal structure of the Apo-PRMT9 shown in cartoon representation and color coded according to its domain architecture as labeled. The unresolved linker joining the two modules is displayed as a black dashed line. (B) Electrostatic surface potential representation of the Apo-PRMT9 shown in the same orientation as in (A). Surface color indicates electrostatic potential ranging from −10 kT/e (red) to +10 kT/e (blue). Electrostatic surface potentials were calculated using APBS.36 (C) Overlay of the Apo-PRMT9 monomer, color coded the same as in (A), on MmPRMT7 (gray) (PDB: 4C4A). (D) Overview of all six missense variants, shown as sticks and colored magenta, distributed among Apo-PRMT9 monomer and color coded the same as in (A).

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