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Figure 8.

ID: ZDB-IMAGE-251219-50
Source: Figures for Stonkus et al., 2025

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Figure Caption

Figure 8.

A hypothetical mechanism (indicated by red dotted arrows) by which the lack of functional PHYHD1 might cause negative effects on cellular physiology under abnormal conditions (such as hypoxia). In this model, the accumulation of 2′-O-Me nucleosides leads to the formation of 2′-O-Me nucleoside triphosphates, resulting in the disruption of RNA transcription or metabolic pathways, such as nucleoside salvage.

Acknowledgments

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