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Figure 7.

ID: ZDB-IMAGE-251130-25
Publication: Ren et al., 2025 - RPGRORF15 Mutations Disrupt Lysosomal Lipid Metabolism in Retinal Pigment Epithelium Cells and Cause Retinitis Pigmentosa
All Figures: Figures for Ren et al., 2025

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Figure Caption

Figure 7.

Knockdown of RPGR^ORF15 resulted in lysosomal degradation dysfunction rather than early phagocytosis in RPE-1 cells. (A) The phagocytosis and degradation capacity of NC and siRPGR^ORF15 RPE-1 cells and (B) quantification of FITC-OS (n = 8). Scale bar = 20 µm. (C) Reduced colocalization between LAMP1 and CTSB in siRPGR^ORF15 RPE-1 cells. Scale bar = 20 µm. Data are presented as mean ± SD. Statistical significance is indicated as not significant (ns), *P < 0.05, **P < 0.01.

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