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Fig. 10 Proposed role of TECPR2 in regulating cargo recycling to the plasma membrane.
TECPR2 is a Rab5 effector, implying that Rab5 directly interacts with and recruits TECPR2 on early endosomes. TECPR2 localizes to endocytosed active Itgβ1-containing endosomes and interacts with the Itgβ1 sorting adaptor, SNX17, and the actin nucleation-promoting factor WASH complex. TECPR2 acts as a linker between Rab5 and cargo retrieval machinery (SNX17 and WASH complex), promoting their recruitment to early endosomes, which in turn mediates the recycling of cargo (integrin) receptors to the plasma membrane. Accordingly, TECPR2 depletion leads to reduced localization of SNX17 and subunits of the WASH complex on early endosomes and impaired retrieval of integrin receptors from the lysosomal degradation pathway. WT refers to wild-type cells. Created in BioRender. Sharma, M. (2025)