ZFIN Image: Dominik et al., 2025, Figure 2

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Figure Caption

Figure 2 Genetic and clinical presentation of individuals harboring ARHGAP19 variants.

(A) Pedigrees of affected families showing segregation of the biallelic ARHGAP19 variants identified. Clinical images presenting the spectrum of disease severity in (B) P1 (F1-II:1), (C) P3 (F3-II:1) (D) P10 (F9-II:4) (E) P2 (F2-II:5) (F) P17 (F15-II:3) (G) P20 (F18-II:1) (H) P22 (F21-II:2) and (I) P23 (F21-II:3), with predominant distal lower limb wasting, foot deformity, relatively mild thinning of intrinsic hand muscles and prominent sandal gap (except P17 (F15-II:3) who presented with acute left-hand weakness and still has upper limb–predominant disease).

Acknowledgments

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