ZFIN Image: Toso et al., 2025, Figure 5

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Figure Caption

Figure 5

Canrenone, dihydrotestosterone, pregnenolone,promegestone, mifepristone dihydroprogesterone, finerenone and eperone fully antagonized hMR and zfMR

(A–H) Dose-response curves of canrenone (A), dihydrotestosterone (B), pregnenolone (C), promegestone (D) mifepristone (E), dihydroprogesterone (F), finerenone (G), and eplerenone (H) in UG5LN-GAL4-hMR and UG5LN-GAL4-zfMR cells. Chemicals were tested in the presence of aldosterone 10⁻⁹ M in UG5LN-GAL4-hMR cells and 0.5 10⁻⁹ M in UG5LN-GAL4-zfMR cells (antagonism test). Results are expressed as the percentage of the maximum luciferase activity induced by 10⁻⁸ M aldosterone. The curves are presented as a non-linear regression; log (ligand) versus response. IC₅₀ values (10⁻⁹ M) are shown in Tables 3 and 4.

Data are presented as means ± SD values. n (replicates per experiment) = 4 per group.

Acknowledgments

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