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Figure 7
The schematic diagram of our findings. PCSK9 acts as a molecular chaperone that promotes LIN28A degradation via the lysosomal pathway. Furthermore, LIN28A, an RNA‐binding protein, ultimately affects the expression of JMY by regulating the transcription factor HES5. Aberrant elevation of JMY influences the organization of the cellular microfilament network, thereby impacting cell morphology.
Acknowledgments
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