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Figure 1.

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Publication: Hall et al., 2025 - Comparison of the Differing Impacts of Lowered N-Acetylglucosaminyltransferase-Ia/b Activity on Motor and Sensory Function in Zebrafish
All Figures: Figures for Hall et al., 2025

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Figure 1.

Characterization of the newly engineered mgat1a−/− zebrafish line. N-glycan types and the sequential processing initiated by GnT-I (mgat1) from oligomannose-type to hybrid-type and conversion of the latter type to complex-type via GnT-II (A). The dashed green box encloses the common pentasaccharide core. Blue, red, and green symbols denote GlcNAc, Fuc, and Man, residues, respectively. N represents Asn residue of an N-glycosylated protein. Agarose gel of genomic DNA fragment digested with BclI from heterozygous and homozygous fish raised from crossing mgat1a+/− fish with indel and Wt alleles (B). DNA Chromatogram of a fragment of mgat1a from a Wt AB fish compared to that of the mgat1a−/− fish, revealing thirteen nucleotide deletions (∆13) (C).

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