IMAGE

Fig. 1

ID

ZDB-IMAGE-251022-51

Genes

ube3a

Antibodies

Publication

Dougnon et al., 2025 - Mutation of ube3a causes developmental abnormalities and autism-like molecular and behavioral alterations in zebrafish

All Figures

Figures for Dougnon et al., 2025

Image

Figure Caption

Fig. 1 Structural and molecular characterization of ube3a mutant zebrafish. (a) Schematic representation of the zebrafish ube3a gene structure showing the 11 exons. The point mutation (T > A) is located in exon 3. (b) Genotyping results showing the WT and mutant alleles. The T > A mutation introduces a unique site difference, allowing the differentiation between WT and mutant alleles. (c) Quantitative real-time PCR (RT—qPCR) analysis of ube3a mRNA relative expression (normalized) at 2, 10 days post-fertilization (dpf) and in adult brain tissue (N = 3 for WT and mutant, each). A reduction in ube3a mRNA levels is observed in mutant fish at larval stages. (d) Western blot analysis of the adult brain. The data are presented as the mean ± SEM. ns: non-significant, *P < 0.05.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Brain Res. Bull.