ZFIN Image: Seaver et al., 2025, Fig. 6

Image

Figure Caption

Fig. 6 Model for how potassium channels and gap junction channels may interact in vivo to determine skeletal patterning. Top: Changes in potassium ion concentration are readily propagated to coupled SPCs via Cx43-GJIC. This activates an unknown voltage-sensitive effector in SPCs, which initiates a cascade that impinges on suppression of evx1 transcription. Joint formation is disfavored. Bottom: Alternatively, when Cx43-GJIC is attenuated changes in ion concentration are not propagated. The voltage-sensitive effector is not activated, permitting evx1 transcription. Joint formation is favored. Created in BioRender. Seaver, A. (2025) https://BioRender.com/4p381ok.

Acknowledgments

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Reprinted from Developmental Biology, , Seaver, A.W., Li, X., Iovine, M.K., Overexpression of potassium channel Kcna5 alters skeletal patterning in the zebrafish regenerating fin, , Copyright (2025) with permission from Elsevier. Full text @ Dev. Biol.