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Fig. 1 Pedigree and panoramic radiograph of family 1 (A) and family 2 (B). Males are marked as squares and females as circles. An arrow indicates the proband, and the black symbols indicate the affected individuals. (C-D) Panoramic radiograph of the patients shows all individuals had a congenital absence of mandibular central incisors. An asterisk marks the congenital missing tooth. Notably, Individual I1 has multiple missing teeth due to age, and the proband III1 has undergone orthodontic treatment
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