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Fig. 4 Zebrafish dennd5b overexpression resulted in a compressed head and a deformed tail phenotype. a Zebrafish standard control RNA injected embryo showed no major signs of physical deformity (no phenotype) at 48 hpf. b-d A mild phenotype, e-g A moderate phenotype, and h-j A severe phenotype emerged due to dennd5b mRNA injection suggesting its critical role in zebrafish early embryonic development. The scale bar represents 890 μm. k Graphical representation of different dosages of mRNA injection resulted in notable physical deformities of a compressed head and a deformed tail phenotype, which occur in a mRNA dose-dependent manner at 48 hpf