ZFIN Image: Wu et al., 2025, Figure 4

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Figure 4

Comparison of histopathological alterations in brain tissues among various treatment groups. (A) Normal histological section of larval brain (40×). (B) Larvae brain exposed to 80 μM AlCl₃ (40×). (C) Larvae brain exposed to AlCl₃ + 4μM Dpz (40×). (D) Larvae brain exposed to AlCl₃ + 4μM C3GG (40×). (E) Larvae brain exposed to AlCl₃ + 4μM C3R (40×). (F) Larvae brain exposed to AlCl₃ + 4μM C3A (40×). (G) Larvae brain exposed to AlCl₃ + 4μM C3S (40×). (H) Larvae brain exposed to AlCl₃ + 4μM C3X (40×). (I) Neuronal density in zebrafish brain. (J) semi-quantitative analysis scores in H&E staining. ## p < 0.01 vs. Con group, * p < 0.05 and ** p < 0.01 vs. model group. (The neurons are highlighted by yellow arrows. Red arrows indicate a small population of neurons exhibiting pyknosis and deeply stained necrosis, whereas green arrows point to areas of midbrain dilation accompanied by balloon-like degeneration).

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Acknowledgments

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