ZFIN Image: Collins et al., 2025, Fig. 3

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Figure Caption

Fig. 3 Loss of Fbxw7 in OLs results in severe myelin outfolds in the optic nerve. a Representative image from transmission electron microscopy (TEM) micrographs of optic nerves from Fbxw7fl/fl and Plp1-CreERT-Fbxw7fl/fl mice at 6-months post-TAM. Outfolds highlighted by arrow. b–e Quantification of number of outfolds (b), severity of outfolds (c), number of myelinated axons (d), and g-ratios (e). Fbxw7fl/fl (N = 4 mice), Plp1-CreERT-Fbxw7fl/fl (N = 3 mice). f Representative images of different myelin abnormalities in Plp1-CreERT-Fbxw7fl/fl optic nerves at 6-months post-TAM. g, h Quantification of OL myelin whorls in Fbxw7fl/fl (N = 4 mice), Plp1-CreERT-Fbxw7fl/fl (N = 3 mice) and double myelinated axons in Fbxw7fl/fl (N = 3 mice), Plp1-CreERT-Fbxw7fl/fl (N = 3 mice). All data displayed as mean ± SEM. Statistical significance determined by unpaired, two-tailed Student’s t test on animal averages. i Example image from pSS cortex of a CASPR+, CNP1+ paranode under MBP+ myelin sheath. Created in BioRender. Emery, B. (2024) BioRender.com/k49b495.

Acknowledgments

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