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Fig. 6 A working model on the role of Ace2 in zebrafish growth and metabolic remodeling. Ace2 deficiency leads to reduced amino acid absorption in the intestine, resulting in growth retardation. Ace2 deficiency also significantly alters the composition and function of the gut microbiota. The host’s energy metabolism shifts from being amino acid-dominant to carbohydrate-dominant. The altered gut microbiota and the shift to carbohydrate metabolism partially compensate for the growth inhibition caused by Ace2 deficiency, even though growth differences remained significant.
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