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Fig. 6 - Supplemental 2 Microridge disorganization in cdc42DN or rac1DN overexpressed keratinocytes. (A–C) Arrowheads indicate disrupted microridges in cdc42DN or rac1DN overexpressed keratinocytes. Differentiated keratinocytes (krt4+) are mosaicly labeled in the Tg(krt4:TetGBDTRE-nVenus-cdc42DN) or Tg(krt4:TetGBDTRE-nVenus-rac1DN). These transgenes were induced by administering Dox and Dex. (E) Significantly reduced branch lengths of microrides in the cdc42DN (P<0.0001, N=40 cells, 7 larvae total) or (F) rac1DN overexpressed cells (p<0.0001, N=66 cells, 6 larvae total). Statistical significances were assessed by Student t test. Scale bars: 20 µm (A, B, C). Error bars indicate mean ± SEM.