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Fig. 5 Functional association of clusters with N04 functional drug categories (A) Schematic of the hypergeometric test for overrepresentation of N04 (anti-Parkinson drugs) by phenotypic BAM cluster 8. (B) Molecular similarity searching based on the MACCS key fingerprints (0-budipine, 1-metixene, 2-piribedil, 3-ropinirole, 4-rasagiline, 5-benzhexol, 6-pergolide, 7-apomorphine, 8-ethopropazine, 9-amantadine). (C) Chemical structures of metixene and ethopropazine. (D) Chemical structures of budipine and amantadine.
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