IMAGE

Fig. 1

ID: ZDB-IMAGE-250820-12
Publication: Ameen et al., 2025 - Genomic Analysis of Glaucoma Pathogenesis Due to gmds Mutation in Zebrafish
All Figures: Figures for Ameen et al., 2025

Image

Figure Caption

Fig. 1 Endophenotypes of glaucoma in heterozygous gmds mutant Zebrafish. Significantly thinner retinal ganglion cell (RGC) layers are found in gmds ± compared to wild-type siblings, as measured by SD-OCT imaging at 6 and 19 months; p = 0.048 and p = 0.0056, respectively) (A–F). H&E staining confirmed reduced RGC numbers in gmds mutants at 24 months; p = 0.003 (G-H, M). Boxed areas at the periphery of the retina are shown in (I and J). Significant optic nerve head width reduction p = 0.0008) is demonstrated in (K–N). Measurements were conducted in duplicate with 5 pairs of wild type and 5 pairs of mutant eyes per group.

Figure Data

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Experimental Eye Research, , Ameen, M.T., Alloway, H., Longjohn, M.N., Gendron, R.L., Paradis, H., Benoukraf, T., French, C.R., Genomic Analysis of Glaucoma Pathogenesis Due to gmds Mutation in Zebrafish, 110497, Copyright (2025) with permission from Elsevier. Full text @ Exp. Eye. Res.