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Fig. 1 - Supplemental 1 Flowchart for identification of causative genes. The processes of candidate gene mapping and gene-based burden analysis were described. The variants in EPHA4 and NGEF identified in each cohort were displayed. Abbreviations: SNP: single-nucleotide polymorphism; eQTL: expression quantitative trait locus; IS: idiopathic scoliosis
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