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Fig. 6 Reduced oxidative stress in recycling adult CM. (a) Representative image of an adult CM exhibiting lower VDAC intensity compared to neighboring cells, as indicated by the yellow arrow. (b) The same CM is positive for the cell cycle marker EdU, as indicated by the yellow arrowhead. Scale bar = 50 µm. (c) The bar graph demonstrates the relative VDAC level in proliferating versus non-proliferating CMs in the parkin-transfected and CCCP-treated group. Data are presented as mean ± SE; * = p ≤ 0.05. Statistical significance was determined using an unpaired t-test, with p ≤ 0.05 considered significant. A minimum four images per condition from one experiment were analyzed. (d) Graphical representation illustrating that the reduction in oxidative stress may facilitate cell cycle progression in adult CMs.