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Fig. 7 Graphical representation of relative levels of (VEGF-A, VEGFR-2, NRP-1A, NRP-2B) protein expression in Zebra fish larvae. A illustrates the extreme significant (p < 0.001) reduction of VEGF-A protein expression in ZER and Combination dose than CIS treated larvae. B states the marginal significant increase (p < 0.05) of VEGFR-2 in CIS treated group, while ZER alone or in combination dose, VEGFR-2 expression is highly reduced by significant fold change. C Note the moderate increase by (1.47 fold) in the Nrp-1 A expression in CIS alone treated group, while ZER alone or combination dose,the Nrp-1A expression is significantly down-regulated by (0.41 fold), (0.62 fold). D Note the extreme significant reduction (p < 0.001) in the Nrp-2B expression in CIS treated group, while ZER alone or combination treatment caused a marginal increase (p < 0.01) in Nrp-2 B expression