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Fig. 5 Analysis of mRNA expression in 3D embryoids after 48 h treatment in vitro. DIV2 embryoids were exposed for 48 h (until DIV4) with different concentration of 5-fluorouracil (A), methotrexate (B), emodin (C), trichosanthin (D), or artemisinin (E). Results represented as mean + SEM values of the mRNA expression (n-fold of control) normalized to β-actin for three independent experiments. Statistical analysis performed with one-way ANOVA followed by Dunnett post hoc comparison test with a significance threshold established at p < 0.05 (*).
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Reprinted from Reproductive toxicology (Elmsford, N.Y.), , Wieloch, J., Blanco, J., Zordick, C., Ohnesorge, N., Schneider, M.R., Barenys, M., Knöspel, F., In vitro embryolethality testing during the peri-implantation stage using 3D mouse embryoids: comparison with 2D mouse cell cultures and the zebrafish embryo model, 108941108941, Copyright (2025) with permission from Elsevier. Full text @ Reprod. Toxicol.