ZFIN Image: Siegerist et al., 2025, Fig. 6

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Fig. 6

Single-cell RNA sequencing analysis of murine doxorubicin-induced nephropathy. A UMAP visualization of all glomerular cells following dimensionality reduction. B Expression patterns of glomerular and immune cell marker genes, confirming the identity of glomerular cell clusters. C Re-clustering of isolated podocytes demonstrated a clear separation between experimental groups. D MAGI2 expression was predominantly detected in the control cluster, with fewer MAGI2-positive cells observed in the experimental groups. E Magi2 mRNA levels were significantly reduced in podocytes following induction of NTS nephritis (p < 0.0001; control n = 1958, doxorubicin n = 407; unpaired t-test with Welch’s correction)

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