ZFIN Image: Siegerist et al., 2025, Fig. 5

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Fig. 5

Single-cell RNA sequencing of isolated glomerular cells in murine NTS nephritis. A UMAP visualization of the entire dataset following dimensionality reduction. B Expression of glomerular and immune cell marker genes, confirming the identity of glomerular cell clusters. C Re-clustering of isolated podocytes revealed a clear separation between the experimental groups. D MAGI2 expression was predominantly observed in the control cluster, with fewer MAGI2-positive cells detected in the experimental groups. E Magi2 mRNA levels were significantly downregulated in podocytes following induction of NTS nephritis (p < 0.0001; control n = 2018, day 1 n = 1639, day 5 n = 1434; one-way ANOVA with Brown-Forsythe correction)

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