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Fig. 1 Zebrafish srrm4 has 2 annotated transcript variants and encodes a protein with a conserved eMIC domain. a) srrm4 transcript variants. Transcript variant 1 (NM_001423807.1) encodes the longer isoform of the Srrm4 protein, which contains the eMIC domain. Transcript variant 2 (XM_021476416.1) has a 16 nt microexon near the 3′ end that creates a frame-shift, resulting in a truncated protein lacking the eMIC domain. The asterisk indicates microexon. Gray shading indicates untranslated regions. b) Sequence alignment of longest isoforms of human, mouse, and zebrafish SRRM4/Srrm4 proteins. The black box outlines the conserved eMIC domain.