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Fig. 8 Model depicting role of mechanical force in regulating expression of genes in tenocytes during onset of active muscle contraction. (A) Cartoon showing role of force in regulating tenocyte morphogenesis and gene expression in tenocytes between 36 and 48 hpf stages correlating with onset of active swimming The variability in gene expression is related to increase in both magnitude and persistence of muscle contraction force. (B) Representative model summarizing the multifaceted role of muscle contractile force on expression dynamics of matn1, klf2a, and mxra5b genes in cranial tendon attachments. (C) Force-responsive gene expression is more nuanced than a binary on/off control.