ZFIN Image: Schloss et al., 2025, Fig 8

Image

Figure Caption

Fig 8 Proposed model.

(A) In wild type animals, Cdh16 suppresses stc1l expression in the corpuscles of Stannius. This limits the ability of Stc1l to suppress the function of Papp-aa, allowing for some proliferation and function of ionocytes. As a result, Ca²⁺ is taken up from the environment and normal acoustic startle thresholds are maintained. (B) In cdh16 mutant animals, suppression of stc1l expression is relieved and stc1l is overexpressed. This results in hyper-inhibition of Papp-aa. As a result, Ca²⁺ uptake is severely limited, animals are hypocalcemic, and acoustic response thresholds are lowered.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Biol.