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Fig. 1 Structural analysis of zebrafish Nrf2a and comparison with human NRF2. (A) Domain organization of human NRF2 (hNRF2), with the target binding partners indicated for each domain, and predicted domain organization for zebrafish Nrf2a. All seven Neh domains seem to be present in Nrf2a. (B) 3D-structure of zebrafish Nrf2a predicted with AlphaFold. In this model, long unstructured regions alternate with shorter regions adopting defined secondary structures, mostly α-helices. The Neh domains are represented with the same color code as in panel A. (C) Structural overlay of the AlphaFold-predicted model for zebrafish Nrf2a (light purple) with that of hNRF2 (cyan). The position of the secondary structure elements within the Nrf2a model matches well with those predicted for hNRF2.