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FIGURE 2
Coilin contributes to the innate immune response independent of splicing activity in HFF cells. (A) rMATS analysis for the control (N) versus coilin 2 (I2) KD treated with DMSO comparison. Five differentially alternatively spliced events were calculated with a false discovery rate (FDR) of 0.05. Compared to control (N), coilin (I2) KD increases all DAS classes. (B) An overlay of DAS genes with DEG genes for DMSO treated control (N) versus coilin (I2) KD. (C) DAS GO cluster analysis showing the top differentially expressed terms for the DMSO treated control (N) versus coilin (I2) KD comparison. (D) rMATS analysis for the control (N) versus coilin 2 (I2) KD treated with LPS comparison. Coilin (I2) KD increases all DAS classes compared to control (N). (E) An overlay of DAS genes with DEG genes for LPS treated control (N) versus coilin (I2) KD comparison. (F) DAS GO cluster analysis showing the top differentially expressed terms for the LPS treated control (N) versus coilin (I2) KD comparison.