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Publication: Yong et al., 2025 - Cryo-EM structure of the BLOC-3 complex provides insights into the pathogenesis of Hermansky-Pudlak syndrome
All Figures: Figures for Yong et al., 2025

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Fig. 1 Cryo-EM structure of the BLOC-3 complex. a Cartoon representation incorporating the results of multiple phylogenetic analyses, including subunits from BLOC-3, Mon1-Ccz1-RMC1, and CPLANE, respectively. b Schematic domain organization of human BLOC-3 subunits. Longin domains (LD1 to LD3) and four-helical bundle domains (4HB) are indicated. c Gel filtration profile of the BLOC-3 complex. The horizontal axis represents elution volume, and the vertical axis represents ultraviolet (UV) absorption. The peak and estimated molecular mass of targeted proteins are labeled. The Coomassie blue-stained gel shows the peak fraction of HPS1-HPS4Δloop from gel filtration. d, e Two views of the cryo-EM density (left) and model (right) of the BLOC-3 complex. HPS1 is shown in purple, and HPS4 in pink. The bottom view is a 270° rotation along the horizontal axis of the top view.

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