FIGURE 2

FIGURE 2

The responses of regeneration‐induced genes and regeneration‐response enhancers (RREs) in various injury models. (a) Responses of RREs and respective genes in the inter‐ray incision. EGFP expression was neither observed in all transgenic (Tg) lines at 2 days post injury (dpi) and at any stage of the healing process. Arrowheads indicate the ends of the incision. (b) Responses of RREs and respective genes in the skin exfoliation injury. EGFP expression was not observed in all Tg lines even with this injury method. Circles mark the injured regions. (c) Responses of RRE and respective genes in the fin puncture injury. Arrows indicate the regions of gene expression or RRE response. The EGFP fluorescence of Tg(msxc:egfp) was detected in the proximal side of the hole, but not in the distal side. However, fn1b, junbb, and both RREs showed responses on both proximal and distal sides. Junbb expression was detected by in situ hybridization (ISH). Scale bars, 100 μm. n = 5, respectively.