ZFIN Image: Oyarbide et al., 2025, Figure 4

Image

Figure Caption

Figure 4 Tp53 pathway activation in eif6 mutants does not affect survival rates.

RT-qPCR analysis of tp53 and its targets of WT and eif6 KO on the (A) tp53^+/+ and (B) tp53^M214K/M214K backgrounds. (C) Scheme of the double-heterozygote crosses (eif6^+/–tp53^+/M214K). (D) Percentage of survival for double-heterozygote crosses of eif6^+/–tp53^+/M214K at 8 and 15 dpf. (E) RT-qPCR analysis of tp53 and its targets (*P < 0.05, **P < 0.01, and ***P < 0.001, by 1-way ANOVA), and (F) UPR markers in WT and eif6^ms/ms zebrafish at 5 dpf (*P < 0.05 and ***P < 0.001, by 2-tailed t test). Data represent the mean ± SEM.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Journal of Clin. Invest.