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Fig. 7 Hypothetical model of signalling crosstalk between Mdka-Ptprz1b and the noncanonical Wnt/PCP pathway. Mdka-Ptprz1b signalling facilitates transcription of prickle1b, prickle2a and prickle2b to contribute to Wnt/PCP signalling. Mdkb acts as an antagonist of Mdka-Ptprz1b signalling likely through competing with Mdka for Ptprz1b binding to prevent receptor activation or by inducing receptor dimer formation to inhibit intracellular protein tyrosine phosphatase activity
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Reprinted from Developmental Biology, , Le, Y., Rajasekhar, K., Loo, T.Y.J., Saunders, T.E., Wohland, T., Winkler, C., Midkine-a interacts with Ptprz1b to regulate neural plate convergence and midline formation in the developing zebrafish hindbrain, , Copyright (2025) with permission from Elsevier. Full text @ Dev. Biol.