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Fig. 5 The inhibitory effect of anlotinib combined with osimertinib on NSCLC cell migration was investigated in vivo in zebrafish xenograft models. (A) Representative images and quantitative analysis of cell migration in the H1975 and PC9 zebrafish xenograft models (scale bar, 200 µm). (B) Representative images and quantitative analysis of cell migration in the H1975-OR and PC9-OR zebrafish xenograft models (scale bar, 200 µm). The number of xenografts analyzed is indicated in the corresponding images. P values were calculated by unpaired Student’s t-tests; *, P<0.05; **, P<0.01; ***, P<0.001; NS, not significant. Each data point represents an independent biological replicate. NC, negative control; Osi, osimertinib; Anl, anlotinib; Osi + Anl, osimertinib combined with anlotinib; NSCLC, non-small cell lung cancer.