Figure 6

Figure 6

Analgesic effects of crude venoms from five species of vermivorous cone snail on zebrafish larvae. (a) Analgesic effects of crude venoms from five species of vermivorous cone snail on zebrafish larvae, evaluated based on their swimming distance, n = 12. (b) Motion trajectory diagrams for the blank control group, acetic acid model group, and positive drug (Tramadol and Lidocaine) group. Motion trajectories were recorded every 5 s, with instantaneous velocity indicated by color: black (<2 mm/s), green (2–8 mm/s), and red (>8 mm/s). (c) Motion trajectory diagram of zebrafish larvae treated with crude venom from C. caracteristicus. (d) Analgesic effects of C. caracteristicus crude venom on zebrafish larvae, n = 12. (e) Line graph showing movement changes in zebrafish larvae treated with C. caracteristicus venom, measured every two minutes. ** p < 0.01, *** p < 0.001, **** p < 0.0001 versus the acetic acid group.