ZFIN Image: Zhang et al., 2025, Figure 10

Image

Figure Caption

Figure 10

MED15–HIF–CPT1A axis maintains lipid homeostasis and promotes tumor progression. The proposed model suggests that MED15 promotes cancer progression during hypoxia. In hypoxia, stabilized HIFα forms a dimeric complex with HIFβ and binds to the HRE of MED15. MED15 acts as a transcriptional coactivator of HIF, facilitating its binding to the promoter of CPT1A. Due to its role as a HIF-repressed gene, CPT1A protein levels decrease, leading to increased storage of fatty acids in the cytoplasm as LD, thereby promoting tumor progression. CPT1A, carnitine O-palmitoyltransferase 1; HIF, hypoxia-inducible factor; MED15, Mediator complex subunit 15.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Biol. Chem.