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Fig. 7 Hypothesis for the regulation of cyp3a65 by zfAhR2, zfPXR and zfGR. While zfAhR2 and zfPXR link to their own response elements in the core of the cyp3a65 promoter, the binding of zfGR to zfHNF4α, itself linked to specific response elements downstream of the cyp3a65 promoter, modulates its expression. zfAhR2 and zfPXR agonist ligands promote the expression of cyp3a65 and zfGR inhibits its constitutive expression. XRE, PXRE and HNF-RE: response elements for zfAhR2, zfPXR and zfHNF4α respectively.
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Full text @ Aquat. Toxicol.