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Fig. 6 Baicalein inhibits the effect of ISO on cardiac dysfunction in vivo. (a) Representative echocardiographic images of the left ventricle showing ventricular dilation and cardiac dysfunction in heart failure mice, while baicalein inhibited ventricular dilation and cardiac dysfunction. In the ISO group, ejection fraction (b) and shortening fraction (c) decreased significantly, after baicalein intervention, cardiac function increased. Results were presented as mean ±SD (n ≥ 3). ###p < 0.001, versus CON, *p < 0.05, **p < 0.01, versus ISO. (d) HE staining in mouse hearts at day 28 in the different group (scale bars, 50 μm; n ≥ 3 in each group). (e) Masson staining of fibrosis and area quantitation in mouse hearts at day 28 in the different group (scale bars, 50 μm; n ≥ 3 in each group).