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Fig. 2
(A) Principal coordinate analysis (PCoA) of gene expression profiles. (B) GO terms of DEGs after exposure to THM. (C) Circos diagram illustrating the interaction of traits and enriched KEGG pathways. ACT, amino acid transport; ASP, Adipocytokine signaling pathway; AT, axon terminus; ATSS, anterograde trans-synaptic signaling; BP, biological processes; CB, cell body; CC, cellular components; CR, circadian rhythm; CRoGE, circadian regulation of gene expression; CRtHS, cellular response to hormone stimulus; CST, chemical synaptic transmission; DA, distal axon; DT, dendritic tree; ERA, endopeptidase regulator activity; ErbB, ErbB signaling pathway; GPCRB, G protein-coupled receptor binding; GPM, Glycerophospholipid metabolism; HCAvPMAM, homophilic cell adhesion via plasma membrane adhesion molecules; HSV1I, Herpes simplex virus 1 infection; IF, intermediate filament; IFC, intermediate filament cytoskeleton; LAATTA, L-amino acid transmembrane transporter activity; LATFA, ligand-activated transcription factor activity; LD, Lysine degradation; LTA, lipid transporter activity; MAPK, MAPK signaling pathway; MC, myosin complex; MF, molecular functions; mTOR, mTOR signaling pathway; NCA, nuclear receptor activity; NCB, neuronal cell body; Notch, Notch signaling pathway; NPT, neuron projection terminus; NRoGE, negative regulation of endopeptidase activity; NRoHA, negative regulation of hydrolase activity; NSP, neuropeptide signaling pathway; PCL, peptide cross-linking; PGGGA, protein-glutamine gamma-glutamyltransferase activity; RMSP, hormone-mediated signaling pathway; RoEA, regulation of endopeptidase activity; RoT, regulation of transport; RoHA, regulation of hydrolase activity; RtH, response to hormone; SLM, Sphingolipid metabolism; SP, sensory perception; SS, synaptic signaling; STEIA, serine-type endopeptidase inhibitor activity; SC, somatodendritic compartment; TSS, trans-synaptic signaling.