Fig. 3

Fig. 3

(A) PCoA of the metabolomics. (B–D) KEGG pathways of the DEGs and DCMs based on the joint analysis of transcriptomics and metabolomics at 10, 100 ng/L, and 1000 ng/L, respectively. The significance level was verified by p < 0.05. The tail in red or blue represents more up-regulated or down-regulated DEGs and DCMs, respectively. βAM, beta-Alanine metabolism; ABCT, ABC transporters; ASaGM, alanine, aspartate, and glutamate metabolism; ASaNSM, amino sugar and nucleotide sugar metabolism; BM, butanoate metabolism; Calcium, calcium signaling pathway; CM, caffeine metabolism; GoG, glycolysis or Gluconeogenesis; NaNM, nicotinate and nicotinamide metabolism; NLRI, neuroactive ligand-receptor interaction; PMM, pyrimidine metabolism; PPP, pentose phosphate pathway; PRM, purine metabolism; TaHM, taurine and hypotaurine metabolism; TCAC, TCA cycle.