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Fig. 2 Altered locomotor activities of mir-219-1?/?, mir-219-2?/?, and mir-219-3?/? zebrafish larvae.Locomotor activities (A) and total swimming distance of mir-219-1?/? (purple) and wild-type control (black) larvae under LD (B), and locomotor activities (C), period (D), phase (E), and amplitude (F) of mir-219-1?/? (purple) and wild-type control (black) larvae under DD. Data are mean ± SD. n = 3 × 24. Locomotor activities (G) and total swimming distance of mir-219-2?/?(red) and wild-type control (black) larvae under LD (H), and locomotor activities (I), period (J), phase (K), and amplitude (L) of mir-219-2?/?(red) and wild-type control (black) larvae under DD. Data are mean ± SD. n = 3 × 24. Locomotor activities (M) and total swimming distance of mir-219-3?/? (green) and wild-type control (black) larvae under LD (N), and locomotor activities (O), period (P), phase (Q), and amplitude (R) of mir-219-3?/? (green) and wild-type control (black) larvae under DD. Data are mean ± SD. n = 3 × 24. The period, phase and amplitude of its rhythm were analyzed by Classic-JTK and Biodare2. Unpaired two-tailed Student?s t-test was conducted, *P < 0.05, **P < 0.01, ***P < 0.001 vs. WT. See also Figs. S3, S4, and S5.