ZFIN Image: Rajeswari et al., 2024, Fig. 6

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Figure Caption

Fig. 6 Schematic representation of Mr activation as a possible peripheral mechanism leading to adiposity in Pomc mutants. The left panel shows the hypothalamus-pituitary-interrenal (HPI) axis function in the wildtype larvae leading to normal growth post-feeding. The right panel shows that the loss of Pomc leads to a lack of Acth and this leads to a reduced Gr responsiveness and an enhanced Mr responsiveness, which regulates adipogenic genes, including pparg, lpl and fasn, leading to adiposity. Acth, Adrenocorticotropic hormone; Crh, Corticotropin-releasing hormone; fasn, Fatty acid synthase; Gr, Glucocorticoid receptor; lpl, Lipoprotein lipase; Mr, Mineralocorticoid receptor; Pomc, Proopiomelanocortin; ppary, Peroxisome proliferator-activated receptor gamma.

Acknowledgments

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