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Fig. 3 Anti-biofilm activity of the 4-AQ molecules 6, 11 and 24.The molecules were administered at different doses and examined for the ability to a inhibit biofilm formation (at 6.25–50 µM) and b disintegrate 24-hour-old biofilm (25-100 µM) of C. albicans SC5314. Values are the average of a representative experiment performed in quadruplicate ± SD. Statistically significant differences between the treated groups and the control (0.1% DMSO) were determined using one-way ANOVA and the Bonferroni test (n.s. P > 0.5, *** P < 0.001). c Confocal microscopy images of the mixed biofilm of C. albicans (RFP-expressing, M137 strain) and P. aeruginosa PAO1 (GFP-expressing) formed in the presence of 0.1% DMSO (control) or 50 µM of 11 showed that the applied.