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Figure 3

ID: ZDB-IMAGE-250109-285
Publication: Wang et al., 2024 - Insulin like growth factor 2 mRNA binding protein 2 regulates vascular development in cerebral arteriovenous malformations
All Figures: Figures for Wang et al., 2024

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Figure 3

IGF2BP2 regulates LGALS8 expression in endothelial cells. (A) Integrative Genomics Viewer (IGV) tracks displaying RNA-seq reads distribution in LGALS8 mRNA. (B) IGV tracks displaying MeRIP-seq reads distribution in LGALS8 mRNA. (C) qRT-PCR detecting differences in LGALS8 expression between control and IGF2BP2 knockdown endothelial cells. (D) Western blot detecting differences in LGALS8 expression between control and IGF2BP2 knockdown endothelial cells. (E) qRT-PCR detecting differences in LGALS8 expression between control and IGF2BP2-overexpressing endothelial cells. (F) Western blot detecting differences in LGALS8 expression between control and IGF2BP2-overexpressing endothelial cells. (G) The mRNA half-life of LGALS8 transcript in control and IGF2BP2-overexpressing endothelial cells. (H) qRT-PCR detecting differences in LGALS8 expression between control and IGF2BP2 knockdown endothelial cells at specific time points. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.

Acknowledgments

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