ZFIN Image: Wang et al., 2024, Figure 1

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Figure Caption

Figure 1

IGF2BP2 is downregulated in cerebral AVMs and regulates angiogenesis in endothelial cells. (A) Enrichment analysis of downregulated genes between normal tissues and cerebral arteriovenous malformations. (B) Rank plot showing genes enriched in the metabolism of RNA pathway. (C) Box plot showing the expression of IGF2BP2 between cerebral AVMs and normal tissues. (D) qRT-PCR and (E) Western blot detecting the IGF2BP2 knockdown efficiency in endothelial cells. (F) Representative images and (G) statistical analysis of tube formation assay in control and IGF2BP2-deficient endothelial cells. (H) qRT-PCR and (I) Western blotting detecting the IGF2BP2 overexpression in endothelial cells. (J) Representative images and (K) statistical analysis of tube formation assay in control and IGF2BP2-overexpressing endothelial cells. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001.

Acknowledgments

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