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Fig. 3 Effect of apigenin on transcriptome profiles in response to cisplatin stimulation. (A) Venn diagram illustrating specific and overlapping gene expression among control, cisplatin, and apigenin + cisplatin groups. (B-C) Volcano plots depicting DEGs in various treatment groups, with each gene marked in red or blue indicating significant upregulation or downregulation, respectively. (D) GO analysis highlighting differences in DEGs between Control and cisplatin groups. (E) Top 20 KEGG pathways significantly affected after cisplatin treatment. (F) GO analysis comparing apigenin + cisplatin with cisplatin alone in DEGs. (H) Top 20 KEGG pathways significantly influenced following apigenin treatment. CP: cisplatin; API: apigenin; BP: Biological Process; CC: Cellular Component; MF: Molecular Function. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)