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Figure Caption
Fig. 2 A) X-ray co-crystal structure binding mode of pyrrolamide-based inhibitor ULD2 (in cyan sticks) in the ATP-binding site of Escherichia coli DNA gyrase B (in grey cartoon, PDB entry: 7P2M); B) docking binding mode of compound 11 (in yellow sticks) in the ATP-binding site of human TopoIIα (in green cartoon, PDB entry: 4R1F); C) docking binding mode of compound 11 (in yellow sticks) in the ATP-binding site of Hsp90β (in cyan cartoon, PDB entry: 5UCJ). For clarity, only selected amino acid residues are presented as sticks. Hydrogen bonds are presented as black dashed lines.
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Full text @ Eur. J. Med. Chem.