ZFIN Image: Van Dingenen et al., 2024, Fig. 5

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Figure Caption

Fig. 5 Hypothesis of how transthyretin (TTR)-binding inhibition and thyroid hormone receptor (TR) antagonism could be added into the existing fish adverse outcome pathway (AOP) network. The existing AOPs linking thyroperoxidase (TPO) inhibition to impaired anterior swim bladder inflation and altered retinal structure, AOPs 159 and 363 (https://aopwiki.org/), respectively, are indicated in grey/black. The two new candidate molecular initiating events (MIEs) that were identified in the current study as well as additional key events (KEs) related to these candidate MIEs are indicated in color (purple: TTR-binding inhibition, blue: TR antagonism). The dotted line indicates all the mechanisms that are important during embryonic development (above the line) and during larval development (below the line). Created with biorender.com.

Acknowledgments

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